17 days old

*Summer Intern, Downstream Process Development

USA - 2778 Millennium Pharma, Inc.
Boston, MA 02109
  • Job Code
    R0014221

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Job Description

POSITION OBJECTIVES:

Takeda's summer internship program blends real world experience with an extensive overview of the pharmaceutical industry. Knowledgeable mentors will provide guidance as you gain professional hands-on experience. The summer internship program is 12 weeks in length and offers a unique perspective into a world-class pharmaceutical company. Compensation is competitive, and financed temporary housing is available to those who qualify. Our internship program also provides you the opportunity to network with people at Takeda through various planned events and activities.

POSITION ACCOUNTABILITIES:

The position will be responsible for performing small scale viral filtration experiments to improve understanding of the impact of process parameters and protein properties on filter capacity and virus clearance. The project will compare select virus filters and operating conditions with model proteins and is intended to generate data to support filter selection and/or capacity improvement for non-platform processes based on molecule properties and operating conditions. As a part of this study, the project will evaluate commercially available surrogate virus-like particles (VLP) in spiking studies for virus filtration and bench scale chromatography runs and collaborate with the in-process analytics group to evaluate VLP analysis kit.

  • Design experiments to understand impact of process parameters on virus filtration
  • Perform UFDF to generate load material for virus filtration studies
  • Evaluate different types of virus filters and current pipeline molecules to correlate molecule properties with virus clearance capacity
  • Evaluate surrogate virus-like particles with a model protein in chromatography spiking studies and compare results with virus clearance validation study
  • Author development study report
  • Support routine laboratory activities (instrument maintenance, buffer preparations, chromatography column packing etc.) and current programs as needed.

EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:

  • Applicants must be enrolled in a U.S. accredited university for the semester before and immediately following the internship.
  • Applicants must be pursuing a Bachelors degree and have completed at least their sophomore year or be a graduate level a Masters degree
  • For Bachelors and Masters degree students, a major in chemical engineering, biochemical/biological engineering, chemistry, biotechnology, or a similar field.
  • Hands-on, lab-based research experience is highly preferred.
  • The candidate should be familiar with basic engineering principles (e.g., fluid mechanics, heat and mass transfer), protein chemistry, and bioseparations (e.g., chromatography, filtration), among other laboratory skills. Knowledge of design of experiment (DoE) and statistical methods is a plus.
  • The candidate should be a self-starter and be comfortable working in the laboratory, with some direction of an engineer in the Downstream Process Development group. Strong communication, organizational, and record-keeping skills are highly desired.

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Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Paid Intern (Fixed Term) (Trainee)

Time Type

Full time





Posted: 2019-11-25 Expires: 2019-12-24
Sponsored by:
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Sponsored by:
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*Summer Intern, Downstream Process Development

USA - 2778 Millennium Pharma, Inc.
Boston, MA 02109

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