25 days old

Principal Scientist/Associate Director, Rare Disease

Shire Human Genetic Therapies, Inc.
Cambridge, MA 02139
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Job Description

The Principal Scientist/Associate Director (AD) will serve as the project team leader and single point of accountability for products being developed in the Rare Disease Drug Discovery Unit (RD DDU) programs in rare and orphan diseases. The primary focus of this role will be in the selection of disease targets and leading a team through the discovery process to deliver therapeutics through in vitro and in vivo proof of concept in clinically relevant disease models with the goal of delivering high quality therapeutics from Research into Clinical Development.


Proactively identify critical path project goals, activities and constraints and propose mitigation plans when necessary

Effectively communicate project status, risks and changes to plan to leadership team

Direct, motivate and hold accountable to goals and timelines all internal and external team members associated with the project

Provide scientific and strategic input into the therapeutic areas target and modality pipeline

Guide a small team of internal scientists and be responsible for their scientific and career development goals

Act as a key liaison with external collaborators and internal stakeholders and help guide research strategy in the focused therapeutic area

Education and competencies:

PhD degree in a biological science discipline, or equivalent with 10 + years of experience or MS with 14+ years of experience or BS with 16+ years of experience in drug discovery and development

5 years of industry experience required

5 years of managerial experience required

The successful candidate will have the following attributes:

Ideally have hands on experience in delivering novel therapeutics from idea to early clinical development.

A background in human genetics, rare and orphan disorders and gene therapy is a strong plus.

The ability to work cooperatively within a cross-functional team setting is critical as are good interpersonal communication skills and a strong attitude of accountability and ownership.

Demonstrate the capability to inspire and motivate others and build authentic relationships

Demonstrate energy, drive and flexibility in order to effectively participate in cross functional teams in a matrix organizational structure.

Strong analytical skills, especially with regard to understanding, interpreting and executing scientific research

Strong organization skills with a track record of timely completion of project deliverables on tight deadlines are required

An in-depth understanding of clinical needs as it relates to guiding early programs towards successful translation to therapeutics that will deliver meaningful benefit to patients

Manage across multiple projects of moderate to large size and scope under minimal supervision.

Contribute specific experimental designs and test conditions based on knowledge gained through prior hands-on experience and/or review of relevant technical literature.

Expected to lead matrix teams in order to deliver on project goals.

Ability to manage and communicate effectively with research vendors including negotiating sponsored research agreements/contracts, analyzing scope of work, facilitating the resolution of actions and issues.

Ability to communicate effectively with key academic opinion leaders, clinical investigators and researchers.

This job posting excludes CO applicants.


USA - MA - Cambridge - Binney St

Worker Type


Worker Sub-Type


Time Type

Full time

Posted: 2021-07-07 Expires: 2021-08-05
Sponsored by:
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Sponsored by:
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Principal Scientist/Associate Director, Rare Disease

Shire Human Genetic Therapies, Inc.
Cambridge, MA 02139

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