6 days old

Research Investigator/Scientist

Shire Human Genetic Therapies, Inc.
Lexington, MA 02421
  • Job Code

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as aResearch Investigator / Scientist in our Lexington, MA office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.


As a member of Analytical Development Structure Characterization team, Research Investigator/ Scientist will work on LC/MS related method development and characterization of in-process samples, drug substance, drug product and reference standards for Takeda biological programs. Responsibilities include designing experiments, execution of experimental studies, documenting results accurately in the laboratory notebooks, writing and reviewing LC/MS technical reports, generating test methods to support testing groups, participate in analytical, process development meetings and discussions.


  • Design and execute LC/MS experiments for biologics characterization, 80%

  • Write protocols, reports, and regulatory filing, 10%

  • Present data to cross-functional teams and provide training to junior scientist as needed.


Education Requirements:

  • Degree in Chemistry, Analytical Chemistry, Biochemistry, or other related discipline

  • Fresh Ph.D. with LC/MS training, 0+ year industry experience

  • MS with 2+ years and BS with 4+ years in LC/MS application after graduation


  • In-depth knowledge biological mass spectrometry (intact mass, peptide mapping for proteins) including both theory and practice is required

  • Knowledge in glycoprotein characterization

  • Experienced in mass spectrometers operation and troubleshooting, e.g Orbitrap, Q-TOF

  • Familiar with LC/MS data processing software, for example, Protein Matrix, Biopharma Finder

  • Experienced in microscale protein sample handling and preparation

  • Experiences in mass spectrometer maintenance

  • Enthusiastic in learning new technology and application in biologics characterization

  • Ability to work successfully in both a team/matrix environment as well as independently

  • Excellent written and verbal communication skills are essential

Complexity and Problem Solving

  • Complex problem-solving skills

  • Ability to manage priorities, flexible to work on multiple projects

Internal and External Contacts

  • Research& Development, Global Biologics, TAU, Biologic Process Development, Drug Product Development, PL&O.

  • CROs and CMOs


  • May require approximately up to 5% travel


  • 401(k) with company match and Annual Retirement Contribution Plan

  • Tuition reimbursement Company match of charitable contributions

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs

Empowering Our People to Shine

Discover more at takedajobs.com

No Phone Calls or Recruiters Please.


*This job posting excludes CO applicants*


Lexington, MA

Worker Type


Worker Sub-Type


Time Type

Full time

Posted: 2021-06-07 Expires: 2021-07-06
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Research Investigator/Scientist

Shire Human Genetic Therapies, Inc.
Lexington, MA 02421

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