27 days old

Scientist, Clinical Pharmacology

Alnylam Pharmaceuticals
Cambridge, MA 02139
  • Job Code
    210124

Scientist, Clinical Pharmacology

Overview

Alnylam is the world's leading RNA interference (RNAi) company.

Founded in 2002, Alnylam was built upon a bold vision of turning scientific possibility into reality by harnessing the power of RNAi for human health as an innovative new class of medicines. We are a growing biopharmaceutical company with three approved medicines and a robust pipeline of investigational medicines focused in four strategic therapeutic areas: genetic medicines, cardio-metabolic diseases, infectious diseases, and central nervous system (CNS) and ocular diseases, including several in late-stage development.

Headquartered in Cambridge, Mass., Alnylam employs over 1,500 people in 19 countries and is rapidly growing globally, with additional offices in Norton, Mass., Maidenhead, U.K., Zug, Switzerland, Amsterdam, Netherlands, and Tokyo, Japan. Alnylam is proud to have been recognized as one of The Boston Globe's Top Places to Work six years in a row (2015-2020), a Great Place to Work in the U.K. and Switzerland two years in a row (2019-2020) and a Science Magazine's Top Employer two years in a row (2019-2020). Please visit www.alnylam.com for more information.

The Scientist in Clinical Pharmacology position will support a rapidly expanding clinical portfolio of promising RNAi therapeutics. The candidate in this position should be well versed in PK and PD with strong ability to critically evaluate and interpret data, conduct noncompartmental analysis, and graphical analysis. In this role, the candidate is expected to have a strong critical thinking ability with excellent oral and written communication skills.

Summary of Key Responsibilities

  • Represent Clinical Pharmacology and provide PKPD support and guidance to Early Development and Clinical Development project teams.
  • Lead the analysis, interpretation, integration and reporting of clinical pharmacokinetic & pharmacodynamic data
  • Conduct PK/PD analyses and data visualization to guide development decisions on project teams; ability to use model-based approaches to aid decision making
  • Provide PKPD input for regulatory submissions such as briefing documents, IND, CTA and MAA/NDA.
  • Contribute to protocol preparation, study execution, data review/analysis, study reports and regulatory document preparation
  • Closely partner with Research, Bioanalytical, Clinical development, Regulatory, Project Management, biostatistics and other R&D functions.
  • Maintain a current understanding of the literature and knowledge in the clinical pharmacology, modeling and simulation field

Qualifications

  • Ph.D. in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with some experience in pharmaceutical industry, or M.D or Pharm.D. with equivalent experience. Level and responsibilities will depend on the individual's experience and skills
  • Strong knowledge of clinical pharmacology principles in drug development including PKPD, modeling and simulation, ADME concepts, and clinical pharmacology.
  • Experience in using R and other data visualization techniques for representation of PKPD data.
  • Proficient in using Phoenix WinNonlin, Phoenix NLME, R, NONMEM, or other pharmacokinetic, modeling software. Training in application of pharmacometric principles or software would be a plus.
  • Strong communication skills (verbal and written) and presentation skills are required.
  • Excellent interpersonal and collaboration skills and the ability to function in a highly matrixed team environment are essential.

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.





Posted: 2021-03-26 Expires: 2021-04-24
Sponsored by:
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Scientist, Clinical Pharmacology

Alnylam Pharmaceuticals
Cambridge, MA 02139

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